Extracellular phospholipase A2(PLA2) is known to be secreted by the mononucleocytes, granulocytes, platelet, and chondrocytes in the joint, and it is also reported that this enzyme is increased in inflammatory conditions, such as acute
panceratitis,
sepsis, ARDS and arthritis. It was proposed that the extracellular release of phospholipase A2 in response to inflammatory stimuli might represent an amplification mechanism for the generation of high levels of lipid mediators such as
eicosanoids.
To
establish the normal value of PLA2 in the healthy individuals we measured extracellular PLA2 of healthy individuals of 84 males and 85 females in their serum and urine.
The levels of PLA2 activity in serum were 170.85±79.92(U/ml) in under 29 years old (20males), 160.68±109.61 in 30 to 39 years old(19 males), 226.58±130.47 in 40 to 49 years old(19 males), 231.10±82.32 tin 50 to 59 years old(17 males),
228.21±102.46
in over 60 years old(6 males), 168.21±62.11(U/ml) in under 29 years old(6 females), 125.85±101.64 in 30 to 39 years old(20 females), 86.70±31.30 in 40 to 49 years old(20 females), 79.00±35.51 in 50 to 59 years old(20 females), 104.74±46.97
in
over
60 years old(19 females). The levels of PLA2 activity in urine were 142.61±141.86(U/ml) in under 29 years old(18 males), 377.85±273.01 in 30 to 39 years old(20 males), 406.16±318.07 in 40 to 49 years old(19 males), 84.34±56.12(U/ml) in under
29
years old(6 females), 17.20±9.94 in 30 to 39 years old(15 females), 54.98±86.24 in 40 to49 years old(15 females), 14.78±11.38 in to 59 years old(18 females), 43.00±40.29 in over 60 years old(19 females).
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